Biochemistry at The Biology Project

Clinical Correlates of pH Levels
Problem Set

Problem 8: Chronic compensation for diet rich in acid

Tutorial to help answer this question

Your patient presents with the following blood gases. When questioned about his diet, he admits to binging on citrus fruits in the past few weeks, and his favorite drinks are grapefruit and tomato juice.

Patient's
Value
Normal
Value
pH 7.32 7.35-7.45
pCO2 25 mm Hg 35-45 mm Hg
[HCO3-] 15 mmol/liter 24-28 mmol/liter

What condition does this patient appear to have?

Tutorial

Compensated metabolic acidosis

Compensated metabolic acidosis would manifest in deviation from normal blood values as highlighted in the table below. Note that the primary defect is indicated by a decrease in bicarbonate ion concentration. (For an explanation as to how this indicates the primary defect, see tutorial for Problem 5.) The compensation is indicated by a decrease in pCO2. This is due to increased CO2 expulsion by the lung, which is the most effective compensation for this metabolic problem. It is worth remembering that any non-respiratory (i.e."metabolic") pH disorder is best compensated in the lung.

respiratory metabolic
acidosis alkalosis acidosis alkalosis
U C U C U C U C
pH decreased decreased decreased decreased
HCO3-:CO2 ratio decreased decreased decreased decreased
[HCO3-] increased decreased decreased decreased decreased decreased
pCO2 decreased decreased decreased decreased decreased increased
total CO2 decreased decreased decreased decreased decreased decreased
increased = increased
decreased = decreased
= no major change
U = uncompensated
C = compensated
increasedincreased = Red arrows indicate the primary defect.
increasedincreased = Green arrows indicate compensation mechanisms.

[Problem 8] [Answer] [Problem 9]

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January 1999
Revised: October 2004
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