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Department of Epidemiology


Spatial Epidemiology




Topic:

The Search for Spatial Associations

Presenter: Daniel Griffith

OVERVIEW and OBJECTIVES

Conventional statistics deal with IID (Independent and Identically Distributed) data; spatial autocorrelation invalidates the independence property of these data. This type of correlation may be viewed as the presence of redundant information in the data. Impacts of positive spatial autocorrelation include:

  • a distortion of tests for normality,
  • inflation of the estimated variance,
  • inflation of the estimated covariance, and
  • the need to estimate an autoregressive model.

Properly accounting for spatial autocorrelation involves estimating the inflation factors, and adjusting the sample size, N -- which becomes the effective sample size, N* -- in order to relate spatially autocorrelated data to equivalent hypothetical IID data. The procedural steps involved in doing this are:

  1. evaluate normality (quantile plots, Shapiro-Wilk statistic), and if necessary apply a power transformation to each variable;
  2. estimate the autoregressive parameter for each georeferenced variable (this lecture employs the Simultaneous AutoRegressive [SAR] model);
  3. estimate the means, inflation factors, and correlation coefficients;
  4. estimate the effective sample size N*, and its associated degrees of freedom;
  5. calculate the t-statistics; and
  6. construct confidence intervals for means and perform significance tests on correlation coefficients.

A variety of georeferenced health data sets are discussed.

OBJECTIVES: Those who successfully complete the module should be able to

  • compute the correct t-statistics for mean georeferenced disease rates, calculated with geographically aggregated data;
  • compute the correct t-statistic for a correlation coefficient calculated with two georeferenced variables, using geographically aggregated data; and
  • apply these concepts to study and analyze data collected by public health agencies.

OUTLINE

LAB

GUESTBOOK


SCENARIOS FOR DISCUSSION